Abstract

AKT is an important regulator of intermediary metabolism, regulating glucose uptake and utilization, pyrimidine biosynthesis and other anabolic processes. To identify differences in metabolic regulation between AKT isoforms, we examined the metabolic profiles of murine isogenic cell lines expressing AKT1, AKT2 or AKT3 under conditions of normoxia or hypoxia. The results will be discussed.